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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/31997/20
    Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia
    Research 2020 : July - September
    Noriyuki Ishihara, Nobuhiro Nishimura, Kazuro Ikawa, Fumi Karino, Kiyotaka Miura, Hiroki Tamaki, Takahisa Yano, Takeshi Isobe, Norifumi Morikawa, Kohji Naora

    The aim of this study was to develop a population pharmacokinetic model for piperacillin\n(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the administration\nplanning by applying pharmacokinetic/pharmacodynamic (PK/PD) criteria. PIPC/TAZ (total dose\nof 2.25 or 4.5 g) was infused intravenously three times daily to Japanese patients over 75 years\nold. The plasma concentrations of PIPC and TAZ were determined using high-performance liquid\nchromatography and modeled using the NONMEM program. PK/PD analysis with a random\nsimulation was conducted using the final population PK model to estimate the probability of\ntarget attainment (PTA) profiles for various PIPC/TAZ-regimenâ??minimum-inhibitory-concentration\n(MIC) combinations...............

    How to Cite this Article
    Attribution/ CC Compliant Citation: Ishihara, Noriyuki, et al. \"Population Pharmacokinetic Modeling and Pharmacodynamic\nTarget Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia.\"\nAntibiotics 9.3 (2020): 113.\nhttps://doi.org/10.3390/antibiotics9030113\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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